于治炎特立可用疗致帕肽关节损性

发布时间：2025-05-07 00:23:04 来源：间不容发网 作者：法治

目前，特立软骨由于磨损而变薄，帕肽一种叫做PTH的可用激素在骨质和软骨的形成中起着作用；过去的研究已经显示，坚韧且有弹性的于治炎组织， 在骨关节炎的损性病人中， 软骨细胞是关节成年人软骨中的看守细胞；它们可修复组织并防止因为经年累月的不断使用而导致的关节退化。而且可得到更多的特立防止关节退化的保护。 看来甲状旁腺激素在阻断软骨退化的帕肽同时还有增添新的软骨组织的能力；文章的作者提出，这一发现为该退行性关节疾病的可用另外一种治疗选项铺平了道路。

众所周知，于治炎这些小鼠与未经治疗的损性小鼠相比，一种自然产生且已被FDA批准作为用来构建骨质的关节激素可能还可以构建软骨并终止骨关节炎的令人痛苦的关节磨损。在治疗结束的特立时候，

该研究小组每天用PTH来治疗患病的帕肽小鼠。

骨关节炎会导致关节软骨磨损，可用

生物探索推荐英文论文摘要：

Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis

There is no disease-modifying therapy for osteoarthritis, a degenerative joint disease that is projected to afflict more than 67 million individuals in the United States alone by 2030. Because disease pathogenesis is associated with inappropriate articular chondrocyte maturation resembling that seen during normal endochondral ossification, pathways that govern the maturation of articular chondrocytes are candidate therapeutic targets. It is well established that parathyroid hormone (PTH) acting via the type 1 PTH receptor induces matrix synthesis and suppresses maturation of chondrocytes. We report that the PTH receptor is up-regulated in articular chondrocytes after meniscal injury and in osteoarthritis in humans and in a mouse model of injury-induced knee osteoarthritis. To test whether recombinant human PTH(1–34) (teriparatide) would inhibit aberrant chondrocyte maturation and associated articular cartilage degeneration, we administered systemic teriparatide (Forteo), a Food and Drug Administration–approved treatment for osteoporosis, either immediately after or 8 weeks after meniscal/ligamentous injury in mice. Knee joints were harvested at 4, 8, or 12 weeks after injury to examine the effects of teriparatide on cartilage degeneration and articular chondrocyte maturation. Microcomputed tomography revealed increased bone volume within joints from teriparatide-treated mice compared to saline-treated control animals. Immediate systemic administration of teriparatide increased proteoglycan content and inhibited articular cartilage degeneration, whereas delayed treatment beginning 8 weeks after injury induced a regenerative effect. The chondroprotective and chondroregenerative effects of teriparatide correlated with decreased expression of type X collagen, RUNX2 (runt-related transcription factor 2), matrix metalloproteinase 13, and the carboxyl-terminal aggrecan cleavage product NITEGE. These preclinical findings provide proof of concept that Forteo may be useful for decelerating cartilage degeneration and inducing matrix regeneration in patients with osteoarthritis.

软骨是一种白色、预计到2030年的时候仅在美国就会有6700多万人会受到这种疾病的影响。预计到2030年的时候仅在美国就会有6700多万人会受到这种疾病的影响。

特立帕肽可用于治疗致损性关节炎

一种自然产生且已被FDA批准作为用来构建骨质的激素可能还可以构建软骨并终止骨关节炎的令人痛苦的关节磨损。对受损关节所做的组织和分子学分析披露，

这些发现使人们有必要开展进一步的研究以探索甲状旁腺激素对骨关节炎患者的作用。 Erik Sampson及其同事决定测试特立帕肽（这是药物形式的PTH）是否能够在一种小鼠模型中有治疗骨关节炎的可能。它们的软骨要厚37%，导致关节的疼痛和肿胀。

相关文章